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Non-severe and severe allergic reactions:

  • Non-severe symptoms include hives or pruritic (itchy) rashes.
  • Severe symptoms include anaphylaxis, angioedema, throat tightening, wheezing plus shock, airway compromise, or cardiovascular collapse. Cardiac collapse requires intervention (eg epinephrine, corticosteroids, vasopressors).
Note: Side effects such as vomiting, abdominal pain, and diarrhea are non-allergic.

Reference: AAP Clinical Practice Guideline: The Diagnosis and Management of Acute Otitis Media Pediatrics; 2013; 131(3); 1451 ‐1465. March 2013.